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KMID : 0869220100140010058
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Journal of Korean Geriatric Psychiatry
2010 Volume.14 No. 1 p.58 ~ p.64
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Comparative Assessment of Clinical Efficacy after 12-Month Clinical Trial of Donepezil between the Patients with Pure Alzheimer’s Disease and Mixed Dementia
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Kang Hyo-Shin
Ahn Inn-Sook
Yun Ji-Hae
Mooon Yu-Jin
Hwang Tae-Young
Lee Young-Min
Kim Hye-Ran
Chung Jae-Won
Kim Doh-Kwan
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Abstract
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Objectives: The purpose of this study was to compare the efficacy of donepezil treatment between patients with pure Alzheimer’s
disease (AD) and Mixed dementia (MD) during a 12-month trial.
Methods: A total of 139 patients were recruited for this 52-week study. The effect of donepezil on cognitive function was measured
using Alzheimer’s Disease Assessment Scale-cognitive subscale-preliminary Korean version (ADAS-cog-K). Patients’ activities of
daily living using the Seoul-Instrumental Activities of Daily Living (S-IADL) and Seoul-Activities of Daily Living (S-ADL)；behavioral
symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline, 13-weeks, 26-weeks,
39-weeks and 52-weeks. We defined the responsive patients to donepezil at those who showed a cognitive improvement or no change
during the first six-month clinical trial.
Results: 84 pure AD patients and 34 MD patients were available for intent-to-treat (ITT) last observation carried forward (LOCF)
analysis. There was no significant difference between two groups in mean change from baseline in the total ADAS-cog-k, S-ADL, SIADL
and K-NPI scores at 52-week. Based on the operational criteria, 60.7% of pure AD patients and 58.8% of MD patients were
responders to donepezil.
Conclusion: MD patients had similar levels of efficacy with pure AD patients and donepezil was well tolerated in both groups.
These results suggest that donepezil is an effective and well-tolerated treatment for MD patients as well as for pure AD patients.
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KEYWORD
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Alzheimer’s Disease·Mixed Dementia·Donepezil·Treatment response.
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